Background: Essential tremor (ET) is a common movement disorder among elderly individuals worldwide and is occasionally associated with a high risk for mild cognitive impairment and dementia.This retrospective study aimed to determine the clinical outcome of unilateral magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy in Chinese patients with ET.Methods: In total, 31 male and 17 female patients with drug-refractory ET were enrolled in this research study from January 2017 to September 2019.The severity of tremor and disability were assessed using the Clinical Rating Scale for Tremor (CRST) within a 2-year click here follow-up period.
Results: The mean age of the participants was 59.14 ± 13.5 years.The mean skull density ratio (SDR) was 0.
5 ± 0.1.The mean highest temperature was 57.0 ± 2.
4°C.The mean number of sonications was 10.0 ± 2.6.
The average maximum energy was 19,710.5 ± 8,624.9 J.The total CRST scores and sub-scores after MRgFUS thalamotomy significantly reduced during each follow-up (p < 0.
001).All but four (8.3%) of the patients had reversible adverse events (AEs) after the click here procedure.Conclusions: MRgFUS had sustained clinical efficacy 2 years after treatment for intractable ET.
Only few patients presented with thalamotomy-related AEs including numbness, weakness, and ataxia for an extended period.Most Chinese patients were treated safely and effectively despite their low SDR.